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. 2013 Apr 29;110(20):8254–8259. doi: 10.1073/pnas.1214696110

Fig. 4.

Fig. 4.

RGS4 is a positive modulator of SSRI and NRI responses. (A) Rgs4KO mice show no response to the SSRI, FLX, at a low dose (20 mg/kg) that reduces immobility time in Rgs4WT mice (n = 7–8 per group; *P < 0.05). (B) When higher doses of FLX are applied (30 mg/kg, n = 5–7 per group; *P < 0.05), both genotypes show similar immobility times. (C) Rgs4KO mice do not respond to a low dose (5 mg/kg) of the NRI, RBX (n = 13–18 per group; *P < 0.05), but both genotypes respond to a higher RBX dose (10 mg/kg, n = 8–10 per group; *P < 0.05) (D). Data are expressed as average ± SEM and analyzed by using two-way ANOVA followed by Bonferroni post hoc test. SAL, saline.