Table 2.

Risk effects of the rare and low frequency nonsynonymous variants associated with Behçet disease (BD) and Crohn disease (CD)

Gene	Variant	BD	CD	Function
IL23R	G149R	Protective	Protective	Unknown
	R381Q	Protective	Protective	Reduces interleukin 23 dependent interleukin 17 production
TLR4	D299G	Protective	Risk	Reduces response to LPS
	T399I	Protective	Risk	Reduces response to LPS
NOD2	R702W	Protective	Risk	Reduces response to MDP
	G908R	Protective	Risk	Reduces response to MDP
	L1007fs	Protective	Risk	Reduces response to MDP
MEFV	M694V	Risk	Risk	Increases response to LPS