Table A3.
Hierarchical linear modelling of the effect of parental schizophrenia on offspring school performance in half-cousin, full cousin and half-sibling datasets using different combination of covariates.
Model 1. Half-cousin comparisons | ||||||
---|---|---|---|---|---|---|
Covariates selections | ||||||
No covariates | Gender | With interactiona | ||||
Estimate | P-value | Estimate | P-value | Estimate | P-value | |
Intercept | −0.22 | <.0001 | −0.77 | <.0001 | −1.81 | <.0001 |
Exposure | ||||||
within extended family | −0.29 | 0.002 | −0.29 | 0.002 | 0.17 | 0.561 |
between extended family | −0.36 | 0.001 | −0.36 | 0.001 | −0.25 | 0.011 |
Education | ||||||
within extended family | - | - | - | - | 0.18 | 0.004 |
between extended family | - | - | - | - | 0.27 | <.0001 |
Gender | ||||||
Male | - | - | −0.37 | <.0001 | −0.37 | <.0001 |
Female | - | - | 0 | - | 0 | - |
Interaction (offspring gender × parental schizophrenia status) | - | - | - | - | −0.27 | 0.153 |
Model 2. Full-cousin comparison | ||||||
Intercept | 0.07 | <.0001 | −0.51 | <.0001 | −1.64 | <.0001 |
Exposure | ||||||
within extended family | −0.22 | <.0001 | −0.21 | <.0001 | −0.01 | 0.921 |
between extended family | −0.37 | <.0001 | −0.37 | <.0001 | −0.24 | <.0001 |
Education | ||||||
within extended family | - | - | - | - | 0.19 | <.0001 |
between extended family | - | - | - | - | 0.31 | <.0001 |
Gender | ||||||
Male | - | - | −0.39 | <.0001 | −0.40 | <.0001 |
Female | - | - | 0 | - | 0 | - |
Interaction (offspring gender × parental schizophrenia status) | - | - | - | - | −0.08 | 0.145 |
Model 3. Half-sibling comparison | ||||||
Intercept | −0.31 | <.0001 | −0.84 | 0.006 | −1.89 | <.0001 |
Exposure | ||||||
within extended family | −0.01 | 0.844 | 0.00 | 0.972 | 0.02 | 0.888 |
between extended family | −0.15 | <.0001 | −0.16 | <.0001 | −0.06 | 0.073 |
Education | ||||||
within extended family | - | - | - | - | 0.17 | <.0001 |
between extended family | - | - | - | - | 0.31 | <.0001 |
Gender | ||||||
Male | - | - | −0.36 | <.0001 | − 0.36 | <.0001 |
Female | - | - | 0 | - | 0 | - |
Interaction (offspring gender × parental schizophrenia status) | - | - | - | - | 0.018 | 0.834 |
Note:
The model adjusted for offspring gender, parental education level and an interaction term with offspring gender and exposure status.