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. Author manuscript; available in PMC: 2014 Apr 30.
Published in final edited form as: Biochemistry. 2013 Apr 19;52(17):2849–2861. doi: 10.1021/bi4001613

Figure 1.

Figure 1

Ribbon structure of TTR tetramers, showing Leu82 (blue, on end of EF helix) and Leu110 (red, on strand G). Mutation of either of these leucines to alanine resulted in significantly less binding of Aβ (13).