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Effect of Aβ aggregation state on binding to TTR. (a) Relative amount of Aβ bound to immobilized TTR, as determined by ELISA. Aβ was freshly prepared (day 0) or pre-aggregated for the indicated number of days prior to contact with TTR. (b) Size distribution of Aβ as function of number of days aggregated, ascertained by PICUP crosslinking and gel electrophoresis.
