Table 1.
Results of LR analysis
| Marker | Region | Position (Hg19/GRCh37) | Univariate LR OR (95% C.I.)/P-value | Forward LR OR (95% C.I.)/P-value | Backward LR OR (95% C.I.)/P-value | LR of SNPs significant in forward or backward model |
|---|---|---|---|---|---|---|
| rs2242652 | 1 | 1 280 028 | 0.84 (0.81–0.87)/1.0 × 10−23 | 0.92 (0.88–0.97)/0.002 | 0.96 (0.91–1.01)/0.134 | |
| rs7725218a | 1 | 1 282 414 | 0.88 (0.86–0.91)/3.5 × 10−17 | 0.92 (0.89–0.96)/3.6 × 10−5 | 0.90 (0.87–0.93)/2.6 × 10−12 | 0.92 (0.88–0.95)/9.7 × 10−6 |
| rs2853676a | 2 | 1 288 547 | 1.09 (1.05–1.12)/1.4 × 10−7 | 1.08 (1.05–1.12)/4.9 × 10−6 | 1.06 (1.03–1.10)/7.7 × 10−4 | |
| rs2853669 | 3 | 1 295 349 | 1.12 (1.08–1.15)/2.7 × 10−13 | 1.11 (1.08–1.15)/7.0 × 10−11 | 1.05 (0.98–1.13)/0.131 | |
| rs2736107 | 3 | 1 297 854 | 1.12 (1.08–1.15)/1.4 × 10−11 | 1.16 (1.13–1.20)/3.0 × 10−19 | 1.09 (1.01–1.17)/0.028 | |
| rs13190087a | 4 | 1 298 733 | 1.20 (1.12–1.29)/1.2 × 10−7 | 1.18 (1.10–1.26)/2.2 × 10−6 | 1.19 (1.11–1.27)/1.1 × 10−6 | 1.18 (1.10–1.27)/2.4 × 10−6 |
The table shows SNPs that remained significant after forward or backward stepwise LR (Forward LR, Backward LR) analyses of 44 imputed or genotyped SNPs in the TERT region associated at P < 10−5 with PrCa risk in single SNP analysis (Univariate LR). Additional LR analysis of these six SNPs showed that four SNPs (bold) remained independently significant at P < 0.05, representing four independent regions.
aGenotyped SNPs.