Figure 1.

7,8-Dihydroxyflavone and its synthetic derivative 4′-dimethylamino-7,8- dihydroxyflavone activate TrkB receptor (A) and its downstream MAPK signaling pathway (B) in the striatum of HD mice. A cohort of mice were chronically administered 7, 8-DHF (5 mg/kg/day) or 4′-DMA-7,8-DHF (1 mg/kg/day) from 6 weeks of age. Mice were euthanized and striatum samples were collected 4 h after the last drug administration at 20 weeks of age, and western blotting (IB) was conducted with indicated antibodies. Values are expressed as mean ± SE from four mice in each group. *P< 0.05 compared with the vehicle value; one-way ANOVA with Scheffé post-hoc test.