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. Author manuscript; available in PMC: 2014 May 9.
Published in final edited form as: Mol Cell. 2013 May 9;50(3):309–321. doi: 10.1016/j.molcel.2013.04.017

Figure 2. Transcription-linked histone PTMs and PTIP promote accessibility for AID targeting.

Figure 2

PTMs of active chromatin are found at the μ region of Igh in resting B cells and help to establish a chromatin environment that is permissive for AID targeting. Upon B cell activation, transcription-linked histone PTMs become detectable at downstream switch regions that have been induced to undergo CSR. These inducible histone PTMs at downstream switch regions are dependent on PTIP, at least at the γ3, γ1, and γ2ab regions.