Table 1. Follow-up of the MEN1 putative mutation' carriers.

Medical visit as outpatients	Biannually	Anamnesis and physical examination
Blood sampling	Biannually	TSH, fT4, PRL, ACTH, cortisol, gastrin, fasting insulin, fasting glucagon, fasting glucose, fasting C-peptide, fasting IGF-1, calcium, chloride, phosphate, PTH, liver enzymes
Urine sampling 24-h collect	Biannually	Calciuria Catecholamines (5-HIAA, HVA and VMA)
Imaging studies	When indicated	Parathyroids US
Imaging studies	Every 2 years	MRI of the pituitary sella MRI of the abdomen

Abbreviations: ACTH, adrenocorticotropic hormone; HVA, homovanillic acid; IGF-1, insulin-like growth factor; MEN1, multiple endocrine neoplasia type 1; MRI, magnetic resonance imaging; PRL, prolactin; PTH, parathyroid hormone; TSH, thyroid stimulating hormone; T4, thyroxine; US, ultrasound; VMA, vanillyl mandelic acid; 5-HIAA, 5-hydroxyindoleacetic acid.