Table 2. Association results between 14 traits and their corresponding top SNPs, where top SNPs were selected based on visit 1 results of SardiNIA GWAS, and where z-statistics for Average and SHAVE are based on three visits.
TRAIT | SNP | z1 | z2 | zAVG | zSHAVE | Visit 1 | Visit 2 | Average | SHAVE |
---|---|---|---|---|---|---|---|---|---|
Bilirubin | rs887829 | 27.33 | 27.37 | 31.44 | 31.59 | 4 | 3 | 2 | 1 |
Cholesterol | rs4910742 | −6.25 | −4.96 | −5.88 | −6.04 | 1 | 4 | 3 | 2 |
γ-GT | rs7310409 | −6.29 | −6.52 | −6.53 | −6.69 | 4 | 3 | 2 | 1 |
Glycemia | rs853787 | −7.17 | −7.50 | −8.06 | −8.24 | 4 | 3 | 2 | 1 |
HDL | rs247617 | 8.45 | 8.93 | 10.10 | 10.19 | 4 | 3 | 2 | 1 |
Height | rs3132468 | 5.91 | 5.82 | 5.91 | 5.92 | 3 | 4 | 2 | 1 |
LDL | rs445925 | −5.89 | −6.13 | −6.74 | −6.77 | 4 | 3 | 2 | 1 |
PR-interval | rs6800541 | 6.56 | 5.92 | 7.10 | 7.11 | 3 | 4 | 2 | 1 |
QT-interval | rs12036340 | 6.27 | 5.31 | 7.21 | 7.27 | 3 | 4 | 2 | 1 |
RBC | rs4910742 | 23.39 | 22.19 | 24.16 | 24.26 | 3 | 4 | 2 | 1 |
Serum iron | rs4820268 | 8.77 | 7.52 | 10.43 | 10.66 | 3 | 4 | 2 | 1 |
Transferrin | rs4854761 | 9.58 | 13.04 | 14.96 | 15.40 | 4 | 3 | 2 | 1 |
Triglycerides | rs10401969 | −6.15 | −4.72 | −6.67 | −6.76 | 3 | 4 | 2 | 1 |
Uric acid | rs13145758 | −11.84 | −12.52 | −13.80 | −14.05 | 4 | 3 | 2 | 1 |
Average rank | 3.36 | 3.50 | 2.07 | 1.07 |
The z-statistics are shown in order for visit 1 (z1), visit 2 (z2), Average (zAVG) and SHAVE (zSHAVE). In the next four columns their corresponding ranks within each trait are shown, where 1 is assigned to the most significant and 4 to the least. On the last row, we have the averages of the ranks for each metric.