Table 3. Association results between 14 traits and their corresponding top SNPs, where top SNPs were selected based on visit 2 results of SardiNIA GWAS, where z-statistics for Average and SHAVE are based on three visits.
TRAIT | SNP | z1 | z2 | zAVG | zSHAVE | Visit 1 | Visit 2 | Average | SHAVE |
---|---|---|---|---|---|---|---|---|---|
Bilirubin | rs887829 | 27.33 | 27.37 | 31.44 | 31.59 | 4 | 3 | 2 | 1 |
Cholesterol | rs6511720 | −4.60 | −5.96 | −5.49 | −5.62 | 4 | 1 | 3 | 2 |
γ-GT | rs7310409 | −6.29 | −6.52 | −6.53 | −6.69 | 4 | 3 | 2 | 1 |
Glycemia | rs853787 | −7.17 | −7.50 | −8.06 | −8.24 | 4 | 3 | 2 | 1 |
HDL | rs247617 | 8.45 | 8.93 | 10.10 | 10.19 | 4 | 3 | 2 | 1 |
Height | rs3132468 | 5.91 | 5.82 | 5.91 | 5.92 | 3 | 4 | 2 | 1 |
LDL | rs6511720 | −5.86 | −6.93 | −6.81 | −6.97 | 4 | 2 | 3 | 1 |
PR-interval | rs6795970 | 6.18 | 5.94 | 6.80 | 6.86 | 3 | 4 | 2 | 1 |
QT-interval | rs12143842 | 6.27 | 5.47 | 7.30 | 7.33 | 3 | 4 | 2 | 1 |
RBC | rs4910742 | 23.39 | 22.19 | 24.16 | 24.26 | 3 | 4 | 2 | 1 |
Serum iron | rs855791 | −8.03 | −7.88 | −10.24 | −10.55 | 3 | 4 | 2 | 1 |
Transferrin | rs4854761 | 9.58 | 13.04 | 14.96 | 15.40 | 4 | 3 | 2 | 1 |
Triglycerides | rs6999813 | −5.67 | −7.63 | −6.87 | −6.97 | 4 | 1 | 3 | 2 |
URIC ACID | rs13145758 | −11.84 | −12.52 | −13.80 | −14.05 | 4 | 3 | 2 | 1 |
Average rank | 3.64 | 3.00 | 2.21 | 1.14 |
The z-statistics are shown in order for visit 1 (z1), visit 2 (z2), Average (zAVG) and SHAVE (zSHAVE). The z-statistics are shown in order for visit 1 (z1), visit 2 (z2), Average (zAVG) and SHAVE (zSHAVE). In the next four columns their corresponding ranks within each trait are shown, where 1 is assigned to the most significant and 4 to the least. On the last row, we have the averages of the ranks for each metric.