Table 4. Association results between 14 traits and their corresponding top SNPs, where top SNPs were selected based on multi-study meta-analyses, and z-statistics for Average and SHAVE are based on three visits and results of SardiNIA GWAS.
| TRAIT | SNP | z1 | z2 | zAVG | zSHAVE | Visit 1 | Visit 2 | Average | SHAVE |
|---|---|---|---|---|---|---|---|---|---|
| Bilirubin | rs887829 | 27.33 | 27.37 | 31.44 | 31.59 | 4 | 3 | 2 | 1 |
| Cholesterol | rs646776* | −4.76 | −4.20 | −4.68 | −4.76 | 1 | 4 | 3 | 2 |
| γ-GT | rs7310409 | −6.29 | −6.52 | −6.53 | −6.69 | 4 | 3 | 2 | 1 |
| Glycemia | rs10830963 | 6.32 | 6.34 | 7.38 | 7.50 | 4 | 3 | 2 | 1 |
| HDL | rs247617 | 8.45 | 8.93 | 10.10 | 10.19 | 4 | 3 | 2 | 1 |
| Height | rs724016 | 5.02 | 4.25 | 5.26 | 5.24 | 3 | 4 | 1 | 2 |
| LDL | rs646776* | −5.39 | −5.14 | −5.69 | −5.76 | 3 | 4 | 2 | 1 |
| PR-interval | rs6800541 | 6.56 | 5.92 | 7.10 | 7.11 | 3 | 4 | 2 | 1 |
| QT-interval | rs7550692* | 5.89 | 4.36 | 6.66 | 6.55 | 3 | 4 | 1 | 2 |
| RBC | rs4910742 | 23.39 | 22.19 | 24.16 | 24.26 | 3 | 4 | 2 | 1 |
| Serum iron | rs4820268 | 8.77 | 7.52 | 10.43 | 10.66 | 3 | 4 | 2 | 1 |
| Transferrin | rs4854761* | 9.58 | 13.04 | 14.96 | 15.40 | 4 | 3 | 2 | 1 |
| Triglycerides | rs1260326 | 5.12 | 4.75 | 5.92 | 5.95 | 3 | 4 | 2 | 1 |
| Uric acid | rs9998811* | −11.58 | −12.44 | −13.61 | −13.87 | 4 | 3 | 2 | 1 |
| Average rank | 3.29 | 3.57 | 1.93 | 1.21 | |||||
The z-statistics are shown in order for visit 1 (z1), visit 2 (z2), Average (zAVG) and SHAVE (zSHAVE). In the next four columns their corresponding ranks within each trait are shown, where 1 is assigned to the most significant and 4 to the least. On the last row, we have the averages of the ranks for each metric. *The original SNPs (which were replaced by proxy SNPs from the Metabochip) are: cholesterol (total) rs629301 (R2=1.00), LDL rs629301 (R2=1.00), QT-interval rs2880058(R2=0.92), transferrin rs3811647(R2=0.96) and uric acid rs734553(R2=0.80).