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. 2012 Oct 17;21(6):643–652. doi: 10.1038/ejhg.2012.222

Figure 2.

Figure 2

Improvement of motor performance and weight progression in SMA animals under JNJ-26481585 treatment. (a) Untreated (= Natural History = NH) SMA animals stop in their weight progression around P5 whereas treated animals continue to gain weight until P9 with significant differences between P8 and P10. (b) Untreated SMA NH animals show a rapid decline in tube test performance. JNJ-26481585-treated animals sustain motor performance until P9; N=19 (untreated), N=18 (JNJ-26481585-treated). Bars show mean±SD, **=P<0.01, ***=P<0.001.