Table 2. Association of CLCA4 haplotypes with residual chloride secretion in ICM.

		Reference	Case		Case
		ICM – no Res.	ICM – DIDS Res.	ORa	ICM – Res.	ORa
rs11807298—rs6684219	1–1	0.276	0.595	3.844	0.688	5.720
	1–2	0.613	0.055	0.037	0.250	0.212
	2–1	0.001	0.055		0.000
	2–2	0.110	0.295		0.063
Prawa			0.0013		0.0338
rs113894048—rs6684219	1–1	0.222	0.350	1.885	0.688	7.700
	1–2	0.722	0.350	0.207	0.313	0.175
	2–1	0.056	0.300		0.000
	2–2	0.000	0.000		0.000
Prawa			0.0750		0.0049
rs11807298–rs113894048–rs6684219	1-1-1	0.222	0.300		0.688	7.700
	1-1-2	0.611	0.050	0.033	0.250	0.212
	1-2-1	0.056	0.300		0.000
	2-1-1	0.000	0.050		0.000
	2-1-2	0.111	0.300	3.429	0.063
Prawa			0.0021		0.0200

^aP and OR calculated vs ‘ICM no Res.' as reference.

P_raw: uncorrected P-value for marker combination; P-values corrected for 9 SNPs within block 4 and 5 SNPs are: P_{[ICM DIDS Res.]}=0.0174; P_{[ICM Res.]}=0.059; P-values corrected for the entire data set of 17 SNPs are: P_{[ICM DIDS Res.]}=0.0157; P_{[ICM Res.]}=0.181.

Abbreviations: ICM, intestinal current measurement; ICM – no Res., absence of chloride secretion upon stimulation with carbachol and histamine; ICM – DIDS Res., presence of chloride secretion upon stimulation with carbachol but absence of chloride secretion upon stimulation with histamine after inhibition with DIDS (chloride secretion mediated by alternative ion channels); ICM – Res., presence of chloride secretion upon stimulation with carbachol and presence of chloride secretion upon stimulation with histamine after inhibition with DIDS (chloride secretion mediated by CFTR). Sample sizes are: ICM – no Res.: n=17; ICM – DIDS Res.: n=13; ICM – Res.: n=22.