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Pre-existing antibodies to HA peptides that correlate with pre-vaccine HAI antibody titers (pre-GMT). Individuals were sorted by pre-GMT levels and divided into high or low pre-GMT (A) and reactivities against HA peptides were compared (B). A significantly higher fraction of samples reactive to peptides H1_23, H3_5, H3_8 and BH14 were found in individuals with high pre-GMT compared with low pre-GMT (P<0.05 by Student’s t-test). Red circles=young, green circles=older.
