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. 2013 Apr 30;9:661. doi: 10.1038/msb.2013.18

Figure 2.

Figure 2

The detailed usage of the E. coli metabolic GEM over time. The cumulative and new number of studies published per year separated according to (A) the metabolic reconstruction used (Edwards and Palsson, 2000; Reed et al, 2003; Feist et al, 2007; Orth et al, 2011), (B) in silico (i.e., strictly computational prediction) or combined in silico and in vivo (i.e., computational usage of the model and experimental validation or data generation guided by the model) and (C) the application category of the study. BD, model-driven discovery; BE, studies of evolutionary processes; II, interspecies interaction; ME, metabolic engineering; NA, analysis of network properties; PB, prediction of cellular phenotypes.