Figure 4.

Endocytosis is conserved between yeast and worm SH3 interactomes and is connected to species-specific functions. Gene functions significantly enriched in yeast and worm SH3 interactomes are visualized as an enrichment map (Merico et al, 2010). Nodes represent enriched gene functions in yeast (green), worm (blue), and both organisms (red). Edges link gene functions that share genes. Edge thickness is proportional to number of shared genes and edge color is blue for shared worm genes and green for shared yeast genes. Clusters of functionally related nodes were manually circled and labeled.