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. Author manuscript; available in PMC: 2013 May 20.
Published in final edited form as: Cell Metab. 2011 Dec 7;14(6):804–810. doi: 10.1016/j.cmet.2011.11.004

Figure 1. Glucose and Mitochondrial Fat Metabolism in Human Subjects with Low or High IHTG Content.

Figure 1

2H and 13C isotopomer analysis of plasma glucose and β-hydroxybutyrate by NMR and FFA by GC-MS was used to determine hepatic flux in overnight fasted individuals. Shown are (A) endogenous glucose production and its contributions from gluconeogenesisand glycogenolysis in hexose units, (B) anaplerotic flux as an estimateofpyruvate carboxylase and PEPCK flux and its contribution to pyruvate cycling and gluconeogenesis, (C) hepatic TCA cyclefluxinacetyl-CoA units, (D) apparent β-hydroxybutyrate turnover as an estimate of ketogenesis; (E) correlation between TCA cycle flux and anaplerosis; and (F) FFA turnover as an estimate of systemic lipolysis. Data are presented as means ±SEM (n = 8) with significance declared at p ≤ 0.05 and p ≤ 0.1 considered a trend.