Axial brain slices in the obese and lean groups of neural activation differences observed in contrasts comparing favorite-food cue vs. neutral-relaxing conditions (A) and stress versus neutral-relaxing conditions (B) (threshold of p<0.01, FWE corrected). Obese individuals show increased activation in the insula, putamen, IFG, and MTG in both contrasts; lean individuals do not show such increased activations. The color scale provides t values of the functional activity. Talairach z levels indicated. hypothal, hypothalamus; IFG, inferior frontal gyrus; L, left; MTG, middle temporal gyrus, parahipp, parahippocampus; R, right. (reprinted with permission from (81))