Table 4.

Variables Significantly Impacting Treatment Outcome or Mortality

	Treatment Success		Mortality
	10-Day	30-Day	10-Day	30-Day
Variable	P Values (Univariable Analysis)
Adult vs pediatric (age <18 y)	NS	NS	.02	NS
Underlying disease	NS	NS	NS	NS
Malignancy	NS	NS	.023a	.033a
End-stage liver disease	NS	NS	.0392	.0124a
Acute renal failure	NS	NS	NS	.0295
Breakthrough infection	NS	NS	NS	.0018
Directed therapy drug class
Polyene vs other	NS	NS	NS	.0073a
Polyene vs azole	NS	NS	NS	.0223
Polyene vs echinocandin	NS	NS	NS	.0099
FKS mutation	.0391	NS	NS	.0374
Echinocandin-resistant MIC
Caspofungin	NS	NS	NS	.0119
Micafungin	NS	NS	NS	.025
Prior antifungal Therapy	NS	NS	NS	.005
Azole	NS	NS	NS	.0017a
Under intensive careb	NS	NS	<.0001a	<.001a

Abbreviation: MIC, minimum inhibitory concentration.

^a Variables that remained significant in multivariable analysis.

^b Located in an intensive care unit at the time of initial positive blood culture collection.