Table 4.
Study design for intra-articular injections of hyaluronic acid for osteoarthritis. a
| Study | Type | Patients, n | Follow-up, wk | Treatment Arm | Control Arm | Outcomes Measures |
|---|---|---|---|---|---|---|
| Noel43 | Prospective | 39 | 26 | Hylan G-F 20 | None | VAS |
| Silverstein50 | Prospective | 30 | 26 | 3 injections of Hylan G-F 20 | None | VAS, UCLA, SST |
| Blaine7 | RCT | 456 | 26 | Sodium hyaluronate | Saline | VAS |
| Merolla38 | Retrospective controlled | 84 | 26 | Hylan G-F 20 | Methylprednisolone acetate | Constant-Murley, SPADI, satisfaction |
a
RCT, randomized controlled trial; VAS, visual analog scale; UCLA, University of California–Los Angeles; SST, Simple Shoulder Test; SPADI, Shoulder Pain and Disability Index.