Table 5.
Comparative analysis of the role of critical genes and signalling pathways involved in the carcinogenesis of human breast cancer and canine mammary tumor.
| Human breast cancer | Canine mammary tumor | |
|---|---|---|
| Gene sets/signaling pathways | ||
| P13K/AKT | Upregulation | Upregulation |
| KRAS | Upregulation | Upregulation |
| PTEN | Downregulation | Downregulation |
| Wnt*b catenin | Upregulation | Upregulation |
| MAPK cascade | Upregulation | Upregulation |
| BRCA1 | Downregulation | Downregulation |
| BRCA2 | Upregulation | Upregulation |
| P53 | Downregulation | Downregulation |