Skip to main content
. 2013 Apr 16;108(9):1891–1898. doi: 10.1038/bjc.2013.172

Table 3. Relative risk of CRC according to plasma inflammatory markers.

 
 Quartilea
  
Analyte 1 2 3 4 Ptrendb
CRP
Median (mg l−1) 0.38 0.79 1.49 3.44  
No. of cases/controls 62/131 53/133 73/135 86/133  
Crude RR (95% CI)c 1.00 (reference) 0.86 (0.55–1.33) 1.14 (0.75–1.73) 1.38 (0.90–2.09) 0.04
Multivariate RR (95% CI)d 1.00 (reference) 0.80 (0.51–1.26) 1.07 (0.69–1.64) 1.24 (0.80–1.93) 0.11
Multivariate RR (95% CI)d+BMI (kg m−2) 1.00 (reference) 0.78 (0.50–1.24) 0.91 (0.58–1.41) 1.17 (0.74–1.83) 0.18
Within 2 years of follow-up
 No. of cases/controls 7/24 3/11 8/20 24/27  
 Multivariate RR (95% CI)d+BMI (kg m−2) 1.00 (reference) 1.18 (0.21–6.67) 1.04 (0.23–4.65) 4.73 (1.31–17.1) 0.005
After 2 years of follow-up
 No. of cases/controls 55/107 50/122 65/115 62/106  
 Multivariate RR (95% CI)d+BMI (kg m−2)
 1.00 (reference)
 0.76 (0.47–1.23)
 0.87 (0.53–1.40)
 0.90 (0.54–1.52)
 0.91
IL-6
Median (pg ml−1) 0.73 1.15 1.64 3.42  
No. of cases/controls 54/133 57/132 74/134 89/133  
Crude RR (95% CI)c 1.00 (reference) 1.10 (0.71–1.73) 1.44 (0.93–2.23) 1.70 (1.12–2.59) 0.01
Multivariate RR (95% CI)d 1.00 (reference) 1.06 (0.67–1.68) 1.34 (0.85–2.11) 1.62 (1.05–2.50) 0.02
Multivariate RR (95% CI)d+BMI (kg m−2) 1.00 (reference) 0.99 (0.61–1.59) 1.17 (0.74–1.87) 1.54 (0.99–2.40) 0.02
Within 2 years of follow-up
 No. of cases/controls 3/16 5/23 15/22 19/21  
 Multivariate RR (95% CI)d+BMI (kg m−2) 1.00 (reference) 1.30 (0.22–7.65) 6.27 (1.21–32.63) 6.78 (1.36–33.8) 0.01
After 2 years of follow-up
 No. of cases/controls 51/117 52/109 59/112 70/112  
 Multivariate RR (95% CI)d+BMI (kg m−2)
 1.00 (reference)
 0.96 (0.58–1.59)
 0.94 (0.57–1.56)
 1.26 (0.78–2.05)
 0.21
sTNFR-2
Median (pg ml−1) 2108 2535 2999 3765  
No. of cases/controls 68/133 66/133 78/133 62/133  
Crude RR (95% CI)c 1.00 (reference) 1.01 (0.66–1.53) 1.15 (0.76–1.76) 0.91 (0.58–1.45) 0.77
Multivariate RR (95% CI)d 1.00 (reference) 1.01 (0.66–1.56) 1.15 (0.74–1.79) 0.97 (0.60–1.57) 0.97
Multivariate RR (95% CI)d+BMI (kg m−2) 1.00 (reference) 0.92 (0.59–1.43) 1.07 (0.68–1.68) 0.87 (0.54–1.43) 0.69
Within 2 years of follow-up
 No. of cases/controls 5/15 14/16 14/26 9/25  
 Multivariate RR (95% CI)d+BMI (kg m−2) 1.00 (reference) 3.00 (0.67–13.48) 1.96 (0.45–8.61) 1.69 (0.29–9.77) 0.96
After 2 years of follow-up
 No. of cases/controls 63/118 52/117 64/107 53/108  
 Multivariate RR (95% CI)d+BMI (kg m−2) 1.00 (reference) 0.80 (0.49–1.29) 1.00 (0.62–1.63) 0.89 (0.52–1.51) 0.83

Abbreviations: BMI=body mass index; CI=confidence interval; CRC=colorectal cancer; CRP=C-reactive protein; IL-6=interleukin-6; RR=relative risk; sTNFR-2=soluble tumour necrosis factor receptor 2.

a

Quartiles of plasma inflammatory markers were based on the distribution among the control participants.

b

Tests for linear trend were conducted using the median values for each quartile of analyte.

c

Results were based on conditional logistic regression. Controls were matched to cases on age and date of blood collection.

d

Results were based on conditional logistic regression (matched for age and date of blood collection) with adjustment for CRC in parent or sibling (yes or no), prior lower gastrointestinal endoscopy (yes or no), pack-years of smoking (continuous), alcohol consumption (continuous, g per day), physical activity (continuous, MET hours per week), regular aspirin/NSAID use (yes or no, ⩾2 tablets per week), regular use of multivitamins (yes or no), energy-adjusted intake of folate (including supplements, μg per day, continuous), calcium (including supplements, mg per day, continuous) and total fiber (continuous, g per day), and red meat intake (continuous, serving per day).