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. 2013 May 16;9:687–696. doi: 10.2147/NDT.S35440

Figure 1.

Figure 1

Association between MRS metabolite ratios and cortical Pittsburgh compound-B (PiB) retention ratio on PET.

Notes: The left panel shows the PiB retention ratio PET images in an 82-year-old man with a PiB retention ratio of 2.42, NAA/Cr ratio of 1.51, mi/Cr ratio of 0.58, and Cho/Cr ratio of 0.76. The right panel shows the PiB retention ratio in a 78 year-old woman with a PiB retention ratio PET images of 1.27, NAA/Cr ratio of 1.69, mi/Cr ratio of 0.45, and Cho/Cr ratio of 0.54. The spectra are scaled to the Cr peak. High PiB retention is associated with significantly elevated mI/Cr and Cho/Cr ratio and a trend of lower NAA/Cr ratio.

Abbreviations: Cho, choline; Cr, creatine; mi, myo-inositol; MRS, magnetic resonance spectroscopy; NAA, N-acetyl aspartate; PET, positron emission tomography.