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. 2013 Apr 20;24(5):766–771. doi: 10.1021/bc3006418

Table 1. Antagonistic and Spectroscopic Properties of RU486 and Its Fluorescent Derivatives.

  IC50a RBAb log Pc λexd λemd Φfl
RU486 1.70 ± 0.24 1 (4.72)      
RU486-BODIPY 1.10 ± 0.22 1.5 3.51 ± 0.24 495 505 0.04–0.29
RU486-TAMRA 7.55 ± 1.34 0.2 0.95 ± 0.14 550 578 0.04–0.08
a

Determined from dose–response curve of progesterone-induced alkaline phosphatase activity inhibition. Units are in nM.

b

Relative biological activity as determined by ratio of IC50(RU486) to IC50 of tested compound.

c

Measured using shake flask method. In parentheses: from DrugBank [DB00834].

d

Units are in nm.