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. 2012 Oct 3;32(40):13917–13928. doi: 10.1523/JNEUROSCI.2313-12.2012

Figure 7.

Figure 7.

SK2 overexpression hampers switching from burst to tonic discharge in nRt cells. A, Voltage responses elicited by ramps of currents applied at the offset of hyperpolarizing steps (protocol in inset). Oscillatory discharge was elicited with a 400 ms hyperpolarizing step from −60 to −110/−120 mV. After 100 ms, a depolarizing ramp of 100 ms was applied, followed by a repolarizing ramp of 500 ms. Ramp peaks were increased in 100 pA steps. B, The number of APs within a 200 ms window after ramp peak (gray box underlying the traces) increased linearly with the peak values of the applied current ramps in WT cells (n = 8), but not in SK2-OE cells (n = 11), indicating hampered burst-tonic switch of SK2-OE cells. For each cell, the resulting input–output curve was tested for linearity by calculating the Pearson's correlation coefficient (r). Average values of r significantly differed between genotypes (**p < 0.01). C, D, Analogous experiments as in A and B, except that no hyperpolarization preceded the ramps.