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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Future Oncol. 2012 Aug;8(8):989–998. doi: 10.2217/fon.12.91

Figure 2. The central challenge to using single-parameter enrichment techniques in identifying rare cells.

Figure 2

This example of computational size filtering of a single patient sample demonstrates the limitations of single-parameter enrichment. Assuming an area threshold at the 50% level (allowing for 50% false-negative rates) would result in an overwhelming number of 110,090 false-positive events.

CTC: Circulating tumor cell; HD: High definition; WBC: White blood cell.