Table 1.
Examples of developmental neurotoxicants.
| Category | Compound | Evidence of DNT | |
|---|---|---|---|
| Animals | Humans | ||
| Methylmercury | +++++ | +++++ | |
| Metals | Lead | +++++ | +++++ |
| Manganese | +++ | +++ | |
| Arsenic | +++ | ++ | |
|
| |||
| Solvents | Ethanol | +++++ | +++++ |
| Toluene | ++++ | +++++ | |
|
| |||
| Organophosphates (various) | ++ | ++ | |
| Pesticides | Organochlorines (dieldrin) | + | −− |
| Herbicides (paraquat) | + | −− | |
| Fungicides (maneb) | + | −− | |
|
| |||
| PCBs | ++++ | +++ | |
| PBDEs | +++ | + | |
| Other contaminants | Phtalates | ++ | ++ |
| Bisphenol A | ++ | −− | |
| PFOS/PFOA | + | −− | |
|
| |||
| Natural toxins | Domoic acid | ++ | −− |
|
| |||
| Pharmaceutical drugs | Antiepileptic compounds | ++++ | ++++ |
|
| |||
| Drugs of abuse | Cocaine | ++ | ++ |
PCBs: polychlorinated biphenyls, PBDEs: polybrominated diphenyl ethers, PFOS/PFOA: perfluorooctane sulfate/perfluorooctanic acid. Symbols (+) are arbitrary evaluations by the authors.