Table 2.
Effect of MAOA and MAOB genotypes on SANS subscale scores in 135 females with schizophrenia using multivariate ANOVA analysis.
| SANS sub-scales | Female genotypes | F | P | ||
|---|---|---|---|---|---|
| MAOA/uVNTR | 11 | 13 | 33 | ||
| Affective flattening | 1.75 ± 1.1* | 1.96 ± 1.2 | 2.47 ± 1.1 | 4.24 | 0.016 |
| Alogia | 1.39 ± 1.5 | 1.58 ± 1.2 | 2.06 ± 1.2 | 3.08 | 0.049 |
| Avolition | 2.04 ± 1.3 | 2.16 ± 1.2 | 2.35 ± 1.3 | 0.64 | 0.528 |
| Anhedonia | 2.07 ± 1.3 | 2.07 ± 1.2 | 2.63 ± 1.3 | 3.08 | 0.049 |
| Attention impairment | 1.54 ± 1.3 | 1.56 ± 1.2 | 1.96 ± 1.3 | 1.60 | 0.206 |
|
| |||||
| SANS total | 8.79 ± 5.4 | 9.33 ± 5.2 | 11.47 ± 5.1 | 3.26 | 0.042 |
|
| |||||
| MAOB/rs1799836 | AA | AG | GG | ||
| Affective flattening | 2.13 ± 1.1 | 1.85 ± 1.1 | 2.87 ± 1.4 | 4.85 | 0.009 |
| Alogia | 1.75 ± 1.3 | 1.55 ± 1.2 | 2.19 ± 1.2 | 1.55 | 0.217 |
| Avolition | 2.25 ± 1.2 | 1.96 ± 1.2 | 2.81 ± 1.4 | 2.98 | 0.054 |
| Anhedonia | 2.27 ± 1.3 | 2.11 ± 1.3 | 2.88 ± 1.3 | 2.20 | 0.115 |
| Attention impairment | 1.60 ± 1.3 | 1.75 ± 1.4 | 2.00 ± 1.1 | 0.68 | 0.506 |
|
| |||||
| SANS total | 10.0 ± 5.2 | 9.23 ± 5.2 | 12.75 ± 5.5 | 2.79 | 0.065 |
*Data are presented as Mean ± SD.
Bonferroni's correction adjusted to P ≤ 0.016.