Figure 1.

a-d Functional and structural changes of retinal vessels in colorectal cancer patients in response to bevacizumab infusion. While the diameter of retinal vessels were unaffected by bevacizumab treatment (Figure 1a) it evoked an increase in arteriolar-to-venular ratio (Figure 1b) and a decrease in flicker-induced arterial vasodilation (Figure 1c). The reactivity of retinal arteries to flickering light tended to be lower in patients with a pathological nocturnal blood pressure profile (non-dippers) than in those with physiological nocturnal blood pressure profile (dippers) (Figure 1d). Legend: before (day-1) and after (day + 1) bevacizumab infusion.