Table 3. Stratified Analyses of the GDRS and GRS with 42 SNPs for Sex, Age, Family History of Diabetes, and Obesity Status.
| ROC | IDI | |||
| C statistic (95% CI) | delta ROC-AUC (95% CI) | Absolute IDI (95% CI) | Relative IDI (%) | |
| Women (238 cases and 1,216 non-cases) | ||||
| Genetic markers (42 SNPs) only | 0.581 (0.542–0.621) | - | - | - |
| GDRS only | 0.855 (0.832–0.879) | Ref. | Ref. | Ref. |
| GDRS and genetic markers (42 SNPs) | 0.861 (0.838–0.884) | 0.006 (−0.00–0.013) | 0.0158 (0.0155–0.0162) | 6.20 |
| Men (340 cases and 701 non-cases) | ||||
| Genetic markers (42 SNPs) only | 0.582 (0.546–0.619) | - | - | - |
| GDRS only | 0.812 (0.785–0.839) | Ref. | Ref. | Ref. |
| GDRS and genetic markers (42 SNPs) | 0.820 (0.793–0.846) | 0.008 (−0.000–0.016) | 0.0161 (0.0158–0.0165) | 6.24 |
| Age<50 years (154 cases and 996 non-cases) | ||||
| Genetic markers (42 SNPs) only | 0.589 (0.540–0.637) | - | - | - |
| GDRS only | 0.883 (0.855–0.910) | Ref. | Ref. | Ref. |
| GDRS and genetic markers (42 SNPs) | 0.887 (0.861–0.914) | 0.005 (−0.004–0.014) | 0.0169 (0.0164–0.0173) | 5.25 |
| Age≥50 years (424 cases and 921 non-cases) | ||||
| Genetic markers (42 SNPs) only | 0.577 (0.545–0.609) | - | - | - |
| GDRS only | 0.788 (0.763–0.813) | Ref. | Ref. | Ref. |
| GDRS and genetic markers (42 SNPs) | 0.798 (0.774–0.822) | 0.010 (0.002–0.018) | 0.0161 (0.0159–0.0164) | 7.50 |
a
A positive family history of diabetes was defined as either the mother or the father or a sibling suffered from type 2 diabetes.
b
Obesity was defined as BMI≥30 kg.