Table 4.
Mortality risk for relatively low biochemical parameter values versus referent values
| Study | Reference range | N* | RR for low values vs. referent (95% CI) | Follow-up (months)† |
|---|---|---|---|---|
|
Phosphorus (mg/dL) | ||||
| Block 2004 [10] |
4.0-5.0 |
13,478 |
1.01 (0.95-1.08) |
18 |
| Kalantar-Zadeh 2006 [14] |
5.0-6.0 |
34,636 |
0.99 (0.88-1.12) |
24 |
| Rodriguez-Benot 2005 [24] |
3.0-5.0 |
170 |
0.41 (0.05-3.26) |
97.6 |
| Tangri 2011 [30] |
3.5-5.5 |
4,776 |
1.22 (1.01-1.49) |
24 |
|
Calcium (mg/dL) | ||||
| Block 2004 [10] |
9.0-9.5 |
28,129 |
0.81 (0.77-0.85) |
30 |
| Kalantar-Zadeh 2006 [14] |
9.0-9.5 |
37,662 |
0.93 (0.87-0.98) |
24 |
| Tangri 2011 [30] |
8.4-9.5 |
3,394 |
1.35 (0.24-7.48) |
24 |
|
Parathyroid hormone (pg/mL) | ||||
| Dukkipati 2010 [29] |
300-600 |
648 |
0.72 (0.52-0.95) |
63 |
| Floege 2010 [16] |
150-300 |
2,595 |
1.31 (1.14-1.51) |
20.9 |
| Kalantar-Zadeh 2006 [14] |
200-300 |
33,758 |
0.99 (0.94-1.05) |
24 |
| Tangri 2011 [30] |
151-300 |
5,071 |
0.84 (0.61-1.16) |
24 |
| Tentori 2008 [15] | 100-300 | 17,648 | 1.00 (0.93-1.08) | 18.7 |
CI, confidence interval; RR, risk ratio.
*Sample size includes patients in the reference range plus those with relatively low biochemical parameter values.
†The median or mean (or total, if median was not given) follow-up time in each study.