Figure 3.

[PdCl₂ (L)] significantly suppressed CDDP-resistant gastric cancer cell proliferation in xenograft model. Cells were inoculated in dorsal skin at a concentration of 3 × 10⁶ gastric cancer cells (MKN45 (0), MKN45 (CDDP)) in 200 μL of PBS. At 7 days after tumor inoculation, tumor-bearing mice were given intraperitoneal injection of CDDP, [PtCl₂ (L)] or [PdCl₂ (L)] at a dose of 40 μmol/kg (n = 5 for each). Tumor volumes were monitored for 28 days in control mice (no treatment), and mice treated with CDDP, [PtCl₂ (L)] or [PdCl₂ (L)]. Data are means ± SE. Significance was determined by the Bonferroni-Holm method. **, P < 0.01 relative to controls.