Table 2.
In vitro cytotoxicity assay in CDDP-sensitive and -resistant gastric cancer cell lines
|
MKN28 |
Resistance factor |
IC50(μM) |
|
|---|---|---|---|
| MKN28(0) | MKN28(CDDP) | ||
| [PdCl2(L)] |
1.02 |
78.9 ± 4.0 |
80.8 ± 6.6 |
| L-OHP |
1.19 |
46.4 ± 4.0 |
55.2 ± 3.8 |
| [PtCl2(L)] |
2.54 |
111.7 ± 27.1 |
283.9 ± 19.3 |
| CDDP |
3.37 |
19.4 ± 2.4 |
65.4 ± 4.6 |
| CABDA |
4.33 |
202.9 ± 17.2 |
878.3 ± 34.1 |
|
MKN45 |
Resistance factor |
IC50(μM) |
|
| |
|
MKN45(0) |
MKN45(CDDP) |
| [PdCl2(L)] |
1.14 |
61.2 ± 6.8 |
69.7 ± 4.1 |
| L-OHP |
1.3 |
27.3 ± 1.1 |
35.6 ± 6.7 |
| [PtCl2(L)] |
2.18 |
129.5 ± 14.8 |
282.6 ± 34.5 |
| CDDP |
3.27 |
23.5 ± 2.2 |
77.0 ± 8.5 |
| CABDA | 3.42 | 152.8 ± 3.7 | 522.0 ± 27.4 |