Table 2. Genotype and allele frequencies for rs17277986, rs6584777, rs12251340, rs10884402, rs7078098 and rs950809 SNPs and three genetic modes of inheritance for the five studied polymorphisms in SORCS1 gene.

SNP ID	Group	n	Genotype frequency (%)			P-value	MAF	P-value	Models	OR; 95% CI; Pa
			CC	CT	TT		T		Additive	0.93(0.64,1.36),0.71
rs17277986	AD	236	173(73.3)	60(25.4)	3(1.3)	0.922	0.14	0.719	Dominant	0.92(0.6,1.38),0.69
	Control	233	167(71.7)	63(27)	3(1.3)		0.15		Recessive	0.99(0.2,4.94),0.99
			CC	CT	TT		T		Additive	0.97(0.66,1.41),0.86
rs6584777	AD	236	173(73.3)	60(25.4)	3(1.3)	0.974	0.14	0.863	Dominant	0.96(0.64,1.45),0.85
	Control	233	169(72.5)	61(26.2)	3(1.3)		0.14		Recessive	0.99(0.2,4.94),0.99
			GG	GT	TT		T		Additive	NA
rs12251340	AD	236	236(100)	0(0)	0(0)	NA	0	NA	Dominant	NA
	Control	233	233(100)	0(0)	0(0)		0		Recessive	NA
			GG	GA	AA		A		Additive	0.63(0.49,0.82),<0.001
rs10884402	AD	236	102(43.2)	112(47.5)	22(9.3)	0.0001	0.33	0.0004	Dominant	0.7(0.48,1.02),0.06
	Control	233	81(34.8)	97(41.6)	55(23.6)		0.44		Recessive	0.33(0.2,0.57),<0.001
			TT	TC	CC		C		Additive	1.2 (0.91,1.58),0.208
rs7078098	AD	236	117(49.6)	101(42.9)	18(7.6)	0.325	0.29	0.207	Dominant	1.16 (0.81,1.66),0.428
	Control	233	107(45.9)	99(42.5)	27(11.6)		0.33		Recessive	1.59 (0.85,2.97),0.148
			CC	CT	TT		T		Additive	1.04(0.79,1.36),0.79
rs950809	AD	236	87(36.9)	126(53.4)	23(9.7)	0.036	0.36	0.79	Dominant	1.31(0.9,1.9),0.15
	Control	233	101(43.3)	98(42.1)	34(14.6)		0.36		Recessive	0.63(0.36,1.11),0.11

Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval; MAF, minor allele frequency; NA, not available.

Genotypes and alleles are expressed as number (percentage). P values were calculated by χ² test 3×2 contingency table for genotype distribution and 2×2 contingency table for allele distribution.

^aAdjusting for age and gender.