Table 5. Genotype and allele frequencies for rs17277986, rs6584777 stratified by gender in overall samples, Alzheimer’s patients and controls.
SNP ID | Group | n | Genotype frequency (%) | P-value | MAF | P-value | ||
CC | CT | TT | T | <0.0001 | ||||
rs17277986 | male | 256 | 202(78.9) | 52(20.3) | 2(0.8) | 0.003 | 0.09 | |
female | 213 | 138(64.8) | 71(33.3) | 4(1.9) | 0.19 | |||
CC | CT | TT | T | <0.0001 | ||||
rs6584777 | male | 256 | 203(79.3) | 51(19.9) | 2(0.8) | 0.003 | 0.09 | |
female | 213 | 139(65.2) | 70(32.9) | 4(1.9) | 0.18 | |||
CC | CT | TT | T | 0.79 | ||||
rs17277986 | AD(Female) | 116 | 75(64.6) | 40(34.5) | 1(0.9) | 0.472 | 0.18 | |
Control(Female) | 97 | 63(64.9) | 31(32) | 3(3.1) | 0.19 | |||
CC | CT | TT | T | 0.9 | ||||
rs6584777 | AD(Female) | 116 | 75(64.6) | 40(34.5) | 1(0.9) | 0.446 | 0.18 | |
Control(Female) | 97 | 64(66) | 30(30.9) | 3(3.1) | 0.19 | |||
CC | CT | TT | T | 0.523 | ||||
rs17277986 | AD(Male) | 120 | 98(81.7) | 20(16.7) | 2(1.6) | 0.138 | 0.1 | |
Control(Male) | 136 | 104(76.5) | 32(23.5) | 0(0) | 0.12 | |||
CC | CT | TT | T | 0.61 | ||||
rs6584777 | AD(Male) | 120 | 98(81.7) | 20(16.7) | 2(1.6) | 0.163 | 0.1 | |
Control(Male) | 136 | 105(77.2) | 31(22.8) | 0(0) | 0.11 |
Abbreviations: MAF, minor allele frequency.
Genotypes and alleles are expressed as number (percentage). P values were calculated by χ2 test 3×2 contingency table for genotype distribution and 2×2 contingency table for allele distribution.