Table 6. Haplotype frequencies (>1%) of the five SNPs rs17277986, rs6584777, rs10884402, rs7078098 and rs950809 in SorCS1 gene and their relative risks for Alzheimer’s disease.

	Allele	All	LOAD	Control	Psim	OR (95% CI); P	OR (95% CI);P
	Combination	(n = 469)	(n = 236)	(n = 233)			(after ajustmentd)
	1:C-C-A-T-C	0.03195	0	0.06212	<0.0001	NA	NA
	2:C-C-A-C-C	0.01804	0	0.03647	<0.0001	NA	NA
	3:T-T-A-C-C	0.01081	0	0.02143	<0.0001	NA	NA
Totala	4:C-C-A-T-T	0.31295	0.31208	0.32093	0.971	Reference	Reference
	5:T-T-G-C-C	0.10894	0.11189	0.10636	0.732	0.98(0.60,1.58);0.925	0.91(0.56,1.49);0.716
	6:C-C-G-T-T	0.0268	0.02873	0.02403	0.489	1.04(0.45,2.41);0.925	1(0.42,2.35);0.998
	7:C-C-G-C-C	0.16205	0.17556	0.14852	0.324	1.10(0.72,1.69);0.642	1.12(0.93,1.9);0.608
	8:C-C-G-T-C	0.29709	0.34099	0.2486	0.003	1.32(0.93,1.9);0.121	1.35(0.95,1.94);0.098
Block 1b	1:C-C	0.85608	0.86017	0.85193	0.708	Reference	Reference
	2:T-T	0.14179	0.13983	0.14378	0.916	0.96(0.65,1.4);0.815	0.91(0.62,1.33);0.617
	1:A-T-C	0.03203	NA	0.06496	<0.0001	NA	NA
	2:A-C-C	0.0289	NA	0.05759	<0.0001	NA	NA
Block 2c	3:A-T-T	0.32511	0.33051	0.32091	0.889	Reference	Reference
	4:G-C-C	0.2729	0.28724	0.25941	0.399	0.98(0.7,1.39);0.936	0.97(0.68,1.37);0.85
	5:G-T-T	0.02787	0.03088	0.02399	0.402	1.06(0.46,2.44);0.886	1.04(0.45,2.44);0.918
	6:G-T-C	0.30582	0.34836	0.26181	0.002	1.23(0.86,1.74);0.254	1.26(0.89,1.8);0.195

Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval; Psim, Simulated P values; NA, not available.

^aAlleles in total haplotype were arrayed in order of rs17277986, rs6584777, rs10884402, rs7078098 and rs950809.

^bAlleles in block 1 haplotype were arrayed in order of rs17277986 and rs6584777.

^cAlleles in block 2 haplotype were arrayed in order of rs10884402, rs7078098 and rs950809.

^dAdjusting for age and gender.