Table 5.
Global response rates in all predefined patients subgroups among MITT patients
|
Subgroup |
Anidulafungin |
||
|---|---|---|---|
| Global success % | [n / N] | 95% CI | |
| Neutropenic statusa |
|
|
|
| ANC ≤ 500/mm3 |
50.0 |
[1/2] |
1.3–98.7 |
| ANC > 500/mm3 |
75.7 |
[28/37] |
58.8–88.2 |
| Baseline pathogensb |
|
|
|
| Candida albicans |
71.4 |
[10/14] |
41.9–91.6 |
| C. glabrata |
66.7 |
[4/6] |
22.3–95.7 |
| C. parapsilosis |
100.0 |
[4/4] |
39.8–100.0 |
| C. rugosa |
100.0 |
[1/1] |
2.5–100.0 |
| C. tropicalis |
72.2 |
[13/18] |
46.5–90.3 |
| Previous surgeryc |
|
|
|
| Any surgery |
84.6 |
[11/13] |
54.6–98.1 |
| Abdominal surgery |
87.5 |
[7/8] |
47.3–99.7 |
| Organ transplantation |
|
|
|
| Kidney, liver, or heart |
0.0 |
[0/0] |
Not applicable |
| Elderly status |
|
|
|
| Age ≥ 65 years |
58.8 |
[10/17] |
32.9–81.6 |
| Renal insufficiency |
|
|
|
| Creatinine clearance < 30 ml/min |
54.5 |
[6/11] |
23.4–83.3 |
| Use of central venous catheterc |
|
|
|
| Yes |
81.0 |
[17/21] |
58.1–94.6 |
| Receiving chemotherapyd |
|
|
|
| Yes | 71.4 | [5/7] | 29.0–96.3 |
a Patients with a missing ANC were not included.
b A patient could have had more than one baseline pathogen.
c Up to 1 month before the baseline visit.
d Up to 3 months before the baseline visit.
Abbreviations used: ANC, absolute neutrophil count; CI, confidence interval; MITT, modified intent-to-treat.