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. 2013 May 20;8(5):e64475. doi: 10.1371/journal.pone.0064475

Figure 3. Binding modes of MMs02514408 and FSHP_FB predicted by GOLD and Glide.

Figure 3

(A) Opposite binding modes predicted for MMs02514408 with hFSHR (B) Similar binding modes predicted for FSHP_FB with hFSHR. The GOLD and Glide docked poses are shown as blue and pink sticks respectively. hFSHR is depicted in green cartoon representation. (C) Figure illustrating the importance of two planar hydrophobic groups (phenyl rings A and B) present in FSHP_FB (yellow sticks) for hFSHR binding (Molecular surface representation). Ring A forms cation-π interaction with 101R while ring B is embedded in the hydrophobic pocket of the binding site.