Table 7. Interactions between FSHP and hFSHR in the docked complex.
hFSHR∞ | FSHPţ | Interaction |
104K(Nζ) | O51 | H bond |
104K(Nζ) | O41 | Electrostatic |
101R(Nη2) | O28 | H bond |
101R(Nη2) | Phenyl ring-A | Cation-π |
179K(Nζ) | O17;O14 | H bond |
103E(Oε1) | O51 | H bond |
52R (Cδ) | C61 | Hydrophobic |
52R (Cδ) | C62 | Hydrophobic |
76E(Oε1) | N74 | Electrostatic |
76E(Oε2) | O50 | H bond |
78S(Oγ) | O50 | H bond |
128S(Oγ) | O7 | H bond |
152Q(NεH1) | S9 | H bond |
153D(Oδ2) | O8 | H bond |
153D(Oδ2) | O17 | H bond |
153D(Oδ1) | N15 | H bond |
BSRs are italicised. ţ Refer to Figure S4B for structural details.