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. 2013 May 20;8(5):e63990. doi: 10.1371/journal.pone.0063990

Figure 6. Effect of SP-A on the TLR ligand-induced expression of inflammation markers in the placenta.

Figure 6

RT-PCR analysis of mRNA for IL-1β (A), CCL5 (B), TNF-α (C) and CXCL1 (D) normalized to GAPDH in placentas collected from CD-1 mice on day 14.5 of a 19- to 20-day gestation 8 hours after intrauterine administration of either PBS or PGN+poly(I:C) with or without SP-A. No transcripts were detected for IL-10. Data depicted are expression levels of cytokine for individual mice. N = 7 for control, n = 11 for PGN/poly(I:C), n = 7 for SP-A and n = 12 for SP-A/PGN/poly(I:C). Median values are depicted by a short straight line. P values were calculated by Mann-Whitney U test and compare PGN+poly(I:C) with and without SP-A.