Table 2. SHANK Family Interacting Proteins.
| Domain | Direct Partner | Function | Select References |
|---|---|---|---|
| ANK | α-fodrin, sharpin | Actin-based cytoskeleton, dendritic spine development |
Bockers et al., 2001; Lim et al., 2001 |
| SH3 | GRIP1, Cav1.3, Densin-180 | AMPA receptor trafficking, CREB, Wnt signaling pathways, dendritic spine remodeling, interaction with CaMKII, |
Quitsch et al., 2005; Sala et al., 2001; Sheng and Kim, 2000; Uemura et al., 2004; Zhang et al., 2005 |
| PDZ | GKAP1(SAPAP1), GKAP3(SAPAP3), PSD-93, mGluR1/5, AMPA receptors, β-PIX, ProSAPiP1, LASPER1, ProSAPiP2, PLC-β3 |
Cytoskeleton, dendritic spine formation and remodeling, synaptic transmission and plasticity, self- multimeirzation |
Gundelfinger et al., 2006; Kreienkamp, 2008; Liebau et al., 2009; Wendholt et al., 2006 |
| Proline- rich/Homer and Cortactin binding |
Homer1, Dynamin-2, Abp1, Abi1, Cortactin, IRSp53 |
Arp 2/3 complex, regulation of actin-based cytoskeleton, dendritic spine formation and remodeling , synaptic transmission and plasticity, AMPA receptor endocytosis, |
Haeckel et al., 2008; Lu et al., 2007; Okamoto et al., 2001; Proepper et al., 2007; Qualmann et al., 2004; Soltau et al., 2004; Soltau et al., 2002; Tu et al., 1999 |
| SAM | Shank3 | Synaptic targeting, self- multimerization, Zn2+ binding |
Baron et al., 2006; Boeckers et al., 2005; Naisbitt et al., 1999 |
| SHANK3 full length protein |
ACTN2, CLU, GKAP1, GKAP3, HNRNPC, LZTS3, PICK1, SYNGAP1 |
Shared interactions with PSD- 95. No functional studies described |
Sakai et al., 2011 |
ANK, ankyrin repeat domain; SH3, Src homology 3 domain; PDZ, PSD-95/Discs large/ZO-1 domain; Pro, a proline-rich region containing homer- and cortactin-binding sites; SAM, sterile alpha motif domain; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid