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. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: Psychoneuroendocrinology. 2013 Feb 11;38(9):1553–1564. doi: 10.1016/j.psyneuen.2013.01.004

Figure.4 — (A) Wild type mice were fed a LFD or HFD for 1 wk. Mice were treated with vehicle (V) or methylphenidate (Mphen). Exploration of a familiar and novel object were measured for 5 min. Results are expressed as % investigation of the novel object compared to the familiar object, means ± SEM; n = 8. Bars without a common superscript are different (P < 0.05). (B) Wild type mice were fed a LFD or HFD for 3 wks. Mice were treated with vehicle (V) or methylphenidate (Mphen). Exploration of a familiar and novel object were measured for 5 min. Results are expressed as % investigation of the novel object compared to the familiar object, means ± SEM; n = 8. Bars without a common superscript are different (P < 0.05). (C) Wild type mice were fed a LFD or HFD for 1 wk. Mice were treated with vehicle (V) or reboxetine (rebox). Exploration of a familiar and novel object were measured for 5 min. Results are expressed as % investigation of the novel object compared to the familiar object, means ± SEM; n = 8. Bars without a common superscript are different (P < 0.05). (D) Wild type mice were fed a LFD or HFD for 1 wk. Mice were treated with vehicle (V) or desipramine (desip). Exploration of a familiar and novel object were measured for 5 min. Results are expressed as % investigation of the novel object compared to the familiar object, means ± SEM; n = 8. Bars without a common superscript are different (P < 0.05).

Figure.4 — (A) Wild type mice were fed a LFD or HFD for 1 wk. Mice were treated with vehicle (V) or methylphenidate (Mphen). Exploration of a familiar and novel object were measured for 5 min. Results are expressed as % investigation of the novel object compared to the familiar object, means ± SEM; n = 8. Bars without a common superscript are different (P < 0.05). (B) Wild type mice were fed a LFD or HFD for 3 wks. Mice were treated with vehicle (V) or methylphenidate (Mphen). Exploration of a familiar and novel object were measured for 5 min. Results are expressed as % investigation of the novel object compared to the familiar object, means ± SEM; n = 8. Bars without a common superscript are different (P < 0.05). (C) Wild type mice were fed a LFD or HFD for 1 wk. Mice were treated with vehicle (V) or reboxetine (rebox). Exploration of a familiar and novel object were measured for 5 min. Results are expressed as % investigation of the novel object compared to the familiar object, means ± SEM; n = 8. Bars without a common superscript are different (P < 0.05). (D) Wild type mice were fed a LFD or HFD for 1 wk. Mice were treated with vehicle (V) or desipramine (desip). Exploration of a familiar and novel object were measured for 5 min. Results are expressed as % investigation of the novel object compared to the familiar object, means ± SEM; n = 8. Bars without a common superscript are different (P < 0.05).