. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: Psychoneuroendocrinology. 2013 Feb 11;38(9):1553–1564. doi: 10.1016/j.psyneuen.2013.01.004

Table 7.

Impact of LFD or HFD feeding on gene expression in cerebral hippocampus, hypothalamus and cortex after 1 or 3 weeks of feeding.

		1 week		3 weeks

	Gene	LFD	HFD	LFD	HFD

Hypothalamus	IL-1α^*	1.000 ± 0.161	0.955 ± 0.102	0.717 ± 0.151	0.865 ± 0.108
	IL-1β^*	1.000 ± 0.239	1.005 ± 0.154	0.744 ± 0.201	0.729 ± 0.186
	IL-1R1^*	1.000 ± 0.143	0.915 ± 0.173	1.090 ± 0.189	1.420 ± 0.207
	¹IL-1R2	1.000 ± 0.123	0.909 ± 0.185	1.101 ± 0.105	0.844 ± 0.215
	IL-1RA	1.000 ± 0.288	0.894 ± 0.124	0.984 ± 0.209	1.235 ± 0.379
	TNF-α	1.000 ± 0.207	0.901 ± 0.126	0.867 ± 0.109	0.928 ± 0.177
	IL-6^#	1.000 ± 0.114	0.942 ± 0.066	1.215 ± 0.071	0.963 ± 0.103
	CD45^*	1.000 ± 0.096	1.006 ± 0.028	0.892 ± 0.080	0.859 ± 0.094
	CD11b^*	1.000 ± 0.078	0.977 ± 0.045	0.832 ± 0.037	0.853 ± 0.065
	F4/80^*	1.000 ± 0.065	0.947 ± 0.062	0.793 ± 0.072	0.721 ± 0.057
	NGF^*	1.000 ± 0.081	1.006 ± 0.128	0.814 ± 0.070	0.839 ± 0.070
	BDNF^*	1.000 ± 0.115	1.088 ± 0.133	0.746 ± 0.124	0.649 ± 0.109

Hypothalamus	IL-1α^*	1.000 ± 0.133	1.003 ± 0.114	0.743 ± 0.115	0.799 ± 0.106
	IL-1β	1.000 ± 0.274	0.946 ± 0.143	0.771 ± 0.207	0.979 ± 0.073
	¹IL-1R2	1.000 ± 0.951	0.729 ± 0.119	0.609 ± 0.724	0.724 ± 0.471
	IL-1RA^*	1.000 ± 0.349	0.882 ± 0.249	0.632 ± 0.220	0.454 ± 0.125
	TNF-α^*	1.000 ± 0.172	0.835 ± 0.212	0.649 ± 0.205	0.710 ± 0.126
	¹IL-6⁺	1.000 ± 0.123^a	1.054 ± 0.161^a,b	1.298 ± 0.069^b	0.923 ± 0.109^a
	CD45^*	1.000 ± 0.062	1.029 ± 0.072	0.850 ± 0.044	0.806 ± 0.049
	CD11b^*	1.000 ± 0.081	1.031 ± 0.085	0.913 ± 0.059	0.909 ± 0.095
	¹F4/80^*	1.000 ± 0.043	0.957 ± 0.060	0.736 ± 0.095	0.659 ± 0.043
	NGF	1.000 ± 0.216	0.768 ± 0.153	1.023 ± 0.288	0.800 ± 0.183
	BDNF	1.000 ± 0.100	0.891 ± 0.124	0.876 ± 0.055	0.914 ± 0.087

Cortex	IL-1α^#	1.000 ± 0.102	1.050 ± 0.069	0.844 ± 0.126	1.049 ± 0.084
	¹IL-1β	1.000 ± 0.345	1.240 ± 0.077	1.083 ± 0.211	1.437 ± 0.131
	IL-1R1	1.000 ± 0.255	1.069 ± 0.116	0.868 ± 0.278	1.208 ± 0.201
	IL-1R2	1.000 ± 0.063	0.955 ± 0.064	0.976 ± 0.084	0.962 ± 0.103
	IL-1RA^#	1.000 ± 0.178	1.153 ± 0.104	0.935 ± 0.115	1.212 ± 0.146
	TNF-α	1.000 ± 0.099	0.888 ± 0.104	0.903 ± 0.104	0.991 ± 0.150
	¹IL-6	1.000 ± 0.139	1.042 ± 0.064	1.273 ± 0.120	1.068 ± 0.115
	¹CD45	1.000 ± 0.071	1.115 ± 0.067	0.721 ± 0.629	1.069 ± 0.060
	CD11b	1.000 ± 0.079	1.056 ± 0.073	0.981 ± 0.050	1.050 ± 0.075
	F4/80	1.000 ± 0.069	1.015 ± 0.071	0.960 ± 0.075	0.989 ± 0.076
	NGF^*	1.000 ± 0.067	0.884 ± 0.051	0.765 ± 0.053	0.761 ± 0.071
	BDNF⁺	1.000 ± 0.084^a	0.870 ± 0.037^b	0.830 ± 0.049^b	0.950 ± 0.063^a

Results are expressed as relative fold change in mRNA expression (mRNA), means ± SEM.; n = 6–8. Results within individual rows without a common superscript letter are significantly different.

P < 0.05, significant main effect of time.

P < 0.05, significant main effect of diet.

⁺

P < 0.05, significant time-diet interaction.

Friedman’s two-way ANOVA for non-parametric data used for analysis.