Table 3.

Univariate (A) and multivariable (B) logistic regression analysis of patient and radiologic tumor characteristics as predictors of persistent disease

	Events/n	OR	95 % CI	p value
A
Patient characteristics
Age (years)
Age < 40 years	8/11	1.91	0.33–11.01	0.47
Age 40–55 years	7/12	1.00
Age > 55 years	6/7	4.29	0.39–47.63	0.24
Men	16/18	11.20	1.74–72.30	0.01
Preoperative GH (>27 mU/L)	9/12	1.71	0.29–10.30	0.56
Preoperative IGF-1 (%ULN)		1.00	1.00–1.01	0.32
Time between diagnosis and surgery (years)
First tertile (mean: 0.04)	8/10	4.00	0.55–29.10	0.17
Second tertile (mean: 0.30)	5/10	1.00
Third tertile (mean: 1.40)	8/10	4.00	0.55–29.10	0.17
Received prior GH-lowering medication	6/11	0.32	0.06–1.62	0.17
Preoperative hypopituitarism (≥1 axis)	8/9	4.92	0.52–47.07	0.17
Radiologic tumor characteristics
Tumor size	12/14	4.67	0.78–28.05	0.09
Suprasellar extension	11/15	1.38	0.29–6.60	0.69
Infrasellar extension	13/15	5.09	0.94–34.46	0.06
Parasellar extension	9/10	6.00	0.63–57.00	0.12
Intracavernous ICA encasement	10/12	3.18	0.53–19.05	0.21
B
Men	16/18	11.47	1.61–81.91	0.02
Parasellar extension	9/10	6.24	0.53–74.24	0.15

ULN upper limit of normal range, ICA internal carotid artery