Table 4.
Overview of univariate and multivariable analysis of predictive tumor characteristics of surgical cure (A) and persistent disease (B) published from 2000 onwards
| References | No. patients | Imaging method | Method of tumor classification | Predictors of cure (univariate analysis) | Predictors of cure (multivariable analysis) |
|---|---|---|---|---|---|
| A | |||||
| Biermasz et al. [31] | 59 | NR | Size: according to Hardy and Wilson [16, 17] | None | |
| Extension: according to Hardy and Wilson [16, 17] | |||||
| Invasion: based on surgery | |||||
| De et al. [32] | 90 | MRI | Size: micro/macro (>10 mm) | Size: micro | |
| + CT | Extension: intrasellar/extrasellar | Extension: intrasellar | |||
| Invasion: NR | |||||
| Minniti et al. [33] | 92 | MRI | Size: micro/macro (>10 mm) | Size: micro | Size: micro |
| Extension: according to Wilson [17] | |||||
| Invasion: based on surgery | |||||
| Nomikos et al. [7] | 688 | MRI | Size: micro/macro (>10 mm)/giant (>40 mm) | Size: micro | |
| + CT | Extension: NR | ||||
| Invasion: based on surgery (infiltration) | Invasion: non-invasive | ||||
| Attanasio et al. [34] | 96 | MRI | Size: micro/macro (>10 mm) | None | None |
| Extension: intrasellar/extrasellar | |||||
| Invasion: expanding outside pituitary fossa | |||||
| Jane Jr et al. [35]a | 60 | MRI | Size: micro/meso (>10 mm)/macro (>20 mm) | Size: negative correlation | |
| Extension: according to Knosp [15] | Extension: grade 0–II | Extension: grade 0–II | |||
| Invasion: grade III/IV |
| References | No. patients | Imaging method | Method of tumor classification | Predictors of persistent disease (univariate analysis) | Predictors of persistent disease (multivariable analysis) |
|---|---|---|---|---|---|
| B | |||||
| Kreutzer et al. [36] | 57 | NR | Size: micro/macro (>10 mm) | ||
| Extension: NR | Extension: extrasellar | ||||
| Invasion: based on surgery + pathology | Invasion: dural invasion | Invasion: dural invasion | |||
| Beauregard et al. [37] | 103 | NR | Size: micro/macro (>10 mm) | ||
| Extension: based on Hardy and Wilson [16, 17] (4 grades) | |||||
| Invasion: grade III/IV | Invasion: grade III/IV | Invasion: grade III/IV | |||
| Minniti et al. [33] | 92 | MRI | Size: micro/macro (>10 mm) | ||
| Extension: according to Wilson [17] | Extension: stage B/C and E | Extension: stage E | |||
| Invasion: based on surgery | Invasion: dural invasion | ||||
| Bourdelot et al. [18] | 83 | MRI | Size: 7 grades | Size: > 15 mm | Size: > 15 mm |
| Extension: SSE (4 grades), ISE, ICE (7 grades) | Extension: SSE, ISE, ICE | ||||
| Invasion: reaching optic chiasm | Invasion: invasion | ||||
| Kim et al. [38] | 42 | MRI | Size: micro/macro (>10 mm) | Size: macro | |
| + CT | Extension: according to Knosp [15] | ||||
| Invasion: grade III/IV | Invasion: grade III/IV | ||||
| Gondim et al. [28]a | 67 | MRI | Size: micro/macro (>10 mm) | ||
| Extension: according to Hardy [16] | Extension: class D, III/IV | ||||
| Invasion: NR | |||||
| Campbell et al. [39]a | 26 | MRI | Size: micro/macro (>10 mm) and volume | Size: tumor volume | |
| Extension: according to Hardy [16] | Extension: class III/IV | ||||
| Invasion: according to Knosp [15] | Invasion: grade III/IV | ||||
| Present series, 2012a | 30 | MRI | Size: 7 grades | ||
| Extension: SSE (5 grades), ISE, ICE (7 grades) | Extension: ICE | ||||
| Invasion: encasement ICA (4 grades) |
NR not reported
a Pure endoscopic transsphenoidal surgery