Figure 1.

Effect of aminothiazoles on PGE₂ production stimulated with IL-1β. A, B) Gingival fibroblasts were treated with TH-848 (0.5, 1, 2, and 5 μM; A) or TH-644 (0.5, 1, 2 and 5 μM; B), alone or in combination with IL-1β (0.5 ng/ml) for 24 h, and PGE₂ was analyzed in culture medium. C) Effect of dexamethasone (dex; 1 μM), celecoxib (10 μM), triclosan (3.5 μM), or MK-886 (4 μM), as well as the aminothiazoles TH-848 (2 μM) and TH-644 (2 μM) alone or in combination with IL-1β (0.5 ng/ml) on PGE₂ production. Control (Ctrl) cells were not treated with any inhibitors. Results are presented as means ± sd (n=3). All results represent ≥3 independent experiments. *P < 0.05 vs. IL-1β-stimulated cells.