Figure 8.

Effect of TH-848 on PGE₂ production and cell viability in rat gingival fibroblasts stimulated with IL-1β. Cells were treated with IL-1β (0.3 ng/ml, A; 0.5 ng/ml, B), alone or in combination with TH-848 (2 μM). Control (Ctrl) cells were not treated with TH-848. PGE₂ production was measured by EIA (A), and viability was assessed by MTT assay (B). Results are presented as means ± sd (n=3). *P < 0.05 vs. IL-1β-stimulated cells for PGE₂ production. Results shown represent ≥3 independent experiments.