Figure 1.

Enhanced adenosine turnover following PEG-ADA treatment aggravates weight loss and inflammation following LPS-induced lung injury. A) Mice received 10 U PEG-ADA or vehicle 3 d before and immediately after LPS instillation; tissue was harvested 3 d later. Mice included in the weight curve study were injected again after 7 d. B) Relative weight loss after LPS treatment (3.75 μg LPS/g body weight) in vehicle and PEG-ADA-treated wild-type mice. P values at indicated time points derived from Bonferroni post hoc testing (n=10–11/group). C) BALF derived from PEG-ADA group 3 d after LPS application contains higher leukocyte numbers (n=11–12/group). D) Pulmonary lysates from PEG-ADA-treated mice exhibit higher MPO activity (n=6–10/group). E) Increased albumin content in BALF from PEG-ADA mice harvested on d 3 post-LPS treatment (n=5–6/group).