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. 2013 Jun;27(6):2122–2131. doi: 10.1096/fj.12-214197

Figure 4.

Figure 4.

A2AR antagonism in vitro increases activated Thy-1.2 T-lymphocyte cytokine release, and agonism decreases cytokine release. A) MMP9 release measured by ELISA from activated CD3+ T lymphocytes normalized to unstimulated levels in WT and A2ARKO mice. WT: n = 4; A2ARKO: n = 4. B) Levels of IL-2, IFN-γ, TNF-α, IL-5, IL-4, IL-10, and CCL5 in cell culture medium of activated Thy-1.2+ lymphocytes treated with ZM241385. Vehicle: n = 4; ZM241385: n = 4/group. C) Levels of IL-2, IFN-γ, TNF-α, IL-5, IL-4, IL-10, and CCL5 released in cell culture medium of activated Thy-1.2+ lymphocytes treated with CGS21680 measured by multiplex ELISA. Vehicle: n = 4; CGS21680: n = 4/group. Open bars indicate vehicle-treated cells; solid bars indicate ZM241385-treated (B) or CGS21680-treated (C) cells. *P < 0.05.